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SUN Pin, ZHANG Zhongbin, WU Fen, WAN Junxiang, JIN Xibeng, XIA Zhaolin
Frontiers of Medicine 2007, Volume 1, Issue 3, Pages 320-326 doi: 10.1007/s11684-007-0062-y
Keywords: case-control rs2854451 regression analysis haplotype further research
Genetic association between the polymorphism of cytosolic PLA2 gene family and schizophrenia
Qiong YU PhD, Xiang-Fei MENG PhD, Jie-Ping SHI, Ya-Qin YU PhD,
Frontiers of Medicine 2010, Volume 4, Issue 1, Pages 101-105 doi: 10.1007/s11684-010-0017-6
Keywords: schizophrenia cytosolic phospholipase A2 ligase detection reaction polymorphism
Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies
Lunxiu Qin
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 24-32 doi: 10.1007/s11684-014-0312-8
In this review, we summarize the novel findings from our series of studies on the leading metastasis-related gene, osteopontin (OPN). In our previous gene expression profiling study, OPN was identified as one of the leading genes associated with the metastasis of hepatocellular carcinoma (HCC). We focused on OPN to evaluate its prognostic values and important roles in HCC metastasis. A retrospective study of large cohorts of HCC patients demonstrated that plasma OPN level was one of the leading independent prognostic factors for HCC patients, even in the early stage of HCC, and could serve as a surrogate serologic biomarker for monitoring the treatment response and tumor recurrence after HCC resection. Using both in vitro and in vivoinvestigations, we found that OPN has an important role in metastasis and tumor growth of HCC and is an attractive potential therapeutic target for combating HCC metastasis. We also found that OPN+ HCC cells have much more amplifications at chromosomal regions, and promoter polymorphisms are important in the regulation of OPN expression and tumor growth and lung metastasis of HCC.
Keywords: osteopontin (OPN) hepatocellular carcinoma metastasis prognosis therapeutic target biomarker geneticpolymorphism
Clinical and genetic risk factors for venous thromboembolism in Chinese population
Chen WANG PhD, MD, Zhen-Guo ZHAI PhD, MD, Ying H. SHEN PhD, MD, Lan ZHAO PhD, MD,
Frontiers of Medicine 2010, Volume 4, Issue 1, Pages 29-35 doi: 10.1007/s11684-010-0012-y
Keywords: risk factor stroke prothrombin plasminogen activator inhibitor type-1 polymorphism thrombophilia biomarker
Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie
Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 138-142 doi: 10.1007/s11684-013-0247-5
Keywords: SIPA1 polymorphism metastatic breast cancer survival
Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,
Frontiers of Medicine 2009, Volume 3, Issue 4, Pages 437-442 doi: 10.1007/s11684-009-0074-x
Keywords: natriuretic peptide precursor A coronary heart disease gene polymorphism allelic discrimination polymorphism
Polymorphism of pharmaceutical molecules: perspectives on nucleation
Jie LU, Zhen LI, Xiaolin JIANG,
Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1, Pages 37-44 doi: 10.1007/s11705-009-0294-2
Keywords: development Polymorphism elucidation controversial relationship
Polymorphism and crystal transformation of penicillin sulfoxide
Dingding JING, Yongli WANG, Zhijian CHEN, Lina ZHOU, Jingkang WANG
Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 4, Pages 442-447 doi: 10.1007/s11705-011-1140-x
Keywords: penicillin sulfoxide crystallization polymorphism crystal transformation Raman spectroscopy
TANG Zhongzhi, LI Junyao, YANG Jianhong
Frontiers of Medicine 2008, Volume 2, Issue 2, Pages 178-181 doi: 10.1007/s11684-008-0033-y
Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group
JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong
Frontiers of Medicine 2007, Volume 1, Issue 2, Pages 230-233 doi: 10.1007/s11684-007-0045-z
Keywords: case-control significant difference reaction-restriction fragment C825T polymorphism evidence
ZHAO Yangguo, WANG Aijie, REN Nanqi, ZHAO Yan
Frontiers of Environmental Science & Engineering 2008, Volume 2, Issue 1, Pages 116-121 doi: 10.1007/s11783-008-0018-8
Keywords: technique single-strand proportion bioreactor community diversity fingerprinting technique
Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature
Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 768-780 doi: 10.1007/s11684-023-0982-1
Keywords: machine learning methods hypertrophic cardiomyopathy genetic risk
Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 217-226 doi: 10.1007/s11684-014-0326-2
This study was designed to investigate the contribution of miRNA-122-binding site polymorphism atAlthough rs3783553 did not significantly affect genetic susceptibility to HBV-related HCC, its variant
Keywords: hepatocellular carcinoma (HCC) interaction miRNA-122-binding site IL-1A rs3783553 hepatitis B virus (HBV) mutations
Interplay between diet and genetic susceptibility in obesity and related traits
Tiange Wang, Min Xu, Yufang Bi, Guang Ning
Frontiers of Medicine 2018, Volume 12, Issue 6, Pages 601-607 doi: 10.1007/s11684-018-0648-6
Keywords: diet genetic susceptibility obesity interaction
Optimal design of steel skeletal structures using the enhanced genetic algorithm methodology
Tugrul TALASLIOGLU
Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 4, Pages 863-889 doi: 10.1007/s11709-019-0523-9
Keywords: design optimization genetic algorithm multiple populations neural network
Title Author Date Type Operation
Association of the genetic polymorphism of EPHX1 and EPHX2 with the susceptibility to chronic benzene
SUN Pin, ZHANG Zhongbin, WU Fen, WAN Junxiang, JIN Xibeng, XIA Zhaolin
Journal Article
Genetic association between the polymorphism of cytosolic PLA2 gene family and schizophrenia
Qiong YU PhD, Xiang-Fei MENG PhD, Jie-Ping SHI, Ya-Qin YU PhD,
Journal Article
Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies
Lunxiu Qin
Journal Article
Clinical and genetic risk factors for venous thromboembolism in Chinese population
Chen WANG PhD, MD, Zhen-Guo ZHAI PhD, MD, Ying H. SHEN PhD, MD, Lan ZHAO PhD, MD,
Journal Article
Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer
Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie
Journal Article
The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease
Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,
Journal Article
Polymorphism of pharmaceutical molecules: perspectives on nucleation
Jie LU, Zhen LI, Xiaolin JIANG,
Journal Article
Polymorphism and crystal transformation of penicillin sulfoxide
Dingding JING, Yongli WANG, Zhijian CHEN, Lina ZHOU, Jingkang WANG
Journal Article
Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure, lipid profile
TANG Zhongzhi, LI Junyao, YANG Jianhong
Journal Article
Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group
JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong
Journal Article
community structure in different wastewater treatment processes characterized by single-strand conformation polymorphism
ZHAO Yangguo, WANG Aijie, REN Nanqi, ZHAO Yan
Journal Article
Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature
Journal Article
Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with
Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen
Journal Article
Interplay between diet and genetic susceptibility in obesity and related traits
Tiange Wang, Min Xu, Yufang Bi, Guang Ning
Journal Article